Improved Bone Micro Architecture Healing Time after Implant Surgery in an Ovariectomized Rat
Identifieur interne : 000754 ( Main/Exploration ); précédent : 000753; suivant : 000755Improved Bone Micro Architecture Healing Time after Implant Surgery in an Ovariectomized Rat
Auteurs : Takahiro Takahashi [Japon] ; Takehiro Watanabe [Japon] ; Hiroshi Nakada [Japon] ; Hiroki Sato [Japon] ; Yasuhiro Tanimoto [Japon] ; Toshiro Sakae [Japon] ; Suguru Kimoto [Japon] ; Dindo Mijares [États-Unis] ; Yu Zhang [États-Unis] ; Yasuhiko Kawai [Japon]Source :
- Journal of hard tissue biology [ 1341-7649 ] ; 2016.
Abstract
The present animal study investigated whether oral intake of synthetic bone mineral (SBM) improves peri-implant bone formation and bone micro architecture (BMA). SBM was used as an intervention experimental diet and AIN-93M was used as a control. The SBM was prepared by mixing dicalcium phosphate dihydrate (CaHPO4·2H2O) and magnesium and zinc chlorides (MgCl2 and ZnCl2, respectively), and hydrolyzed in double-distilled water containing dissolved potassium carbonate and sodium fluoride. All rats were randomly allocated into one of two groups: a control group was fed without SBM (n = 18) or an experimental group was fed with SBM (n = 18), at seven weeks old. At 9 weeks old, all rats underwent implant surgery on their femurs under general anesthesia. The implant was inserted into the insertion socket prepared at rats’ femur to a depth of 2.5 mm by using a drill at 500 rpm. Nine rats in each group were randomly selected and euthanized at 2 weeks after implantation. The remaining nine rats in each group continued their diets, and were euthanized in the same manner at 4 weeks after implantation. The femur, including the implant, was removed from the body and implant was pulled out by an Instron universal testing machine. After the implant removal, BMA was evaluated by bone surface ratio (BS/BV), bone volume fraction (BV/TV), trabecular thickness (TbTh), trabecular number (TbN), trabecular star volume (Vtr), and micro-CT images. BS/BV, BV/TV, TbTh and Vtr were significantly greater in the rats were fed with SBM than those were fed without SBM at 2 and 4 weeks after implantation (P < 0.05). The present results revealed that SBM improves the peri-implant formation and BMA, prominent with trabecular bone structure. The effect of SBM to improve secondary stability of the implant, and shortening the treatment period should be investigated in the future study.
Url:
DOI: 10.2485/jhtb.25.257
PubMed: 28133434
PubMed Central: 5267561
Affiliations:
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sortKey="Kawai, Yasuhiko" sort="Kawai, Yasuhiko" uniqKey="Kawai Y" first="Yasuhiko" last="Kawai">Yasuhiko Kawai</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Removable Prosthodontics, Nihon University of Dentistry at Matsudo, Matsudo, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Removable Prosthodontics, Nihon University of Dentistry at Matsudo, Matsudo</wicri:regionArea><wicri:noRegion>Matsudo</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28133434</idno><idno type="pmc">5267561</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5267561</idno><idno type="RBID">PMC:5267561</idno><idno type="doi">10.2485/jhtb.25.257</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">002650</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002650</idno><idno 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Takahashi</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Removable Prosthodontics, Nihon University Graduate School of Dentistry at Matsudo, Removable Prosthodontics, Matsudo, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Removable Prosthodontics, Nihon University Graduate School of Dentistry at Matsudo, Removable Prosthodontics, Matsudo</wicri:regionArea><wicri:noRegion>Matsudo</wicri:noRegion></affiliation></author><author><name sortKey="Watanabe, Takehiro" sort="Watanabe, Takehiro" uniqKey="Watanabe T" first="Takehiro" last="Watanabe">Takehiro Watanabe</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Removable Prosthodontics, Nihon University of Dentistry at Matsudo, Matsudo, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Removable Prosthodontics, Nihon University of Dentistry at Matsudo, Matsudo</wicri:regionArea><wicri:noRegion>Matsudo</wicri:noRegion></affiliation></author><author><name sortKey="Nakada, Hiroshi" sort="Nakada, Hiroshi" uniqKey="Nakada H" first="Hiroshi" last="Nakada">Hiroshi Nakada</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Removable Prosthodontics, Nihon University of Dentistry at Matsudo, Matsudo, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Removable Prosthodontics, Nihon University of Dentistry at Matsudo, Matsudo</wicri:regionArea><wicri:noRegion>Matsudo</wicri:noRegion></affiliation></author><author><name sortKey="Sato, Hiroki" sort="Sato, Hiroki" uniqKey="Sato H" first="Hiroki" last="Sato">Hiroki Sato</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Removable Prosthodontics, Nihon University Graduate School of Dentistry at Matsudo, Removable Prosthodontics, Matsudo, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Removable Prosthodontics, Nihon University Graduate School of Dentistry at Matsudo, Removable Prosthodontics, Matsudo</wicri:regionArea><wicri:noRegion>Matsudo</wicri:noRegion></affiliation></author><author><name sortKey="Tanimoto, Yasuhiro" sort="Tanimoto, Yasuhiro" uniqKey="Tanimoto Y" first="Yasuhiro" last="Tanimoto">Yasuhiro Tanimoto</name><affiliation wicri:level="1"><nlm:aff id="A3">Department of Dental Biomaterials, Nihon University of Dentistry at Matsudo, Matsudo, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Dental Biomaterials, Nihon University of Dentistry at Matsudo, Matsudo</wicri:regionArea><wicri:noRegion>Matsudo</wicri:noRegion></affiliation></author><author><name sortKey="Sakae, Toshiro" sort="Sakae, Toshiro" uniqKey="Sakae T" first="Toshiro" last="Sakae">Toshiro Sakae</name><affiliation wicri:level="1"><nlm:aff id="A4">Department of Histology, Nihon University of Dentistry at Matsudo, Matsudo, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Histology, Nihon University of Dentistry at Matsudo, Matsudo</wicri:regionArea><wicri:noRegion>Matsudo</wicri:noRegion></affiliation></author><author><name sortKey="Kimoto, Suguru" sort="Kimoto, Suguru" uniqKey="Kimoto S" first="Suguru" last="Kimoto">Suguru Kimoto</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Removable Prosthodontics, Nihon University of Dentistry at Matsudo, Matsudo, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Removable Prosthodontics, Nihon University of Dentistry at Matsudo, Matsudo</wicri:regionArea><wicri:noRegion>Matsudo</wicri:noRegion></affiliation></author><author><name sortKey="Mijares, Dindo" sort="Mijares, Dindo" uniqKey="Mijares D" first="Dindo" last="Mijares">Dindo Mijares</name><affiliation wicri:level="2"><nlm:aff id="A5">Department of Biomaterials and Biomimetics, New York University College of Dentistry, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biomaterials and Biomimetics, New York University College of Dentistry, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Zhang, Yu" sort="Zhang, Yu" uniqKey="Zhang Y" first="Yu" last="Zhang">Yu Zhang</name><affiliation wicri:level="2"><nlm:aff id="A5">Department of Biomaterials and Biomimetics, New York University College of Dentistry, New York, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biomaterials and Biomimetics, New York University College of Dentistry, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Kawai, Yasuhiko" sort="Kawai, Yasuhiko" uniqKey="Kawai Y" first="Yasuhiko" last="Kawai">Yasuhiko Kawai</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Removable Prosthodontics, Nihon University of Dentistry at Matsudo, Matsudo, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Removable Prosthodontics, Nihon University of Dentistry at Matsudo, Matsudo</wicri:regionArea><wicri:noRegion>Matsudo</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of hard tissue biology</title><idno type="ISSN">1341-7649</idno><idno type="eISSN">1880-828X</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">The present animal study investigated whether oral intake of synthetic bone mineral (SBM) improves peri-implant bone formation and bone micro architecture (BMA). SBM was used as an intervention experimental diet and AIN-93M was used as a control. The SBM was prepared by mixing dicalcium phosphate dihydrate (CaHPO<sub>4</sub>·2H<sub>2</sub>O) and magnesium and zinc chlorides (MgCl<sub>2</sub> and ZnCl<sub>2</sub>, respectively), and hydrolyzed in double-distilled water containing dissolved potassium carbonate and sodium fluoride. All rats were randomly allocated into one of two groups: a control group was fed without SBM (n = 18) or an experimental group was fed with SBM (n = 18), at seven weeks old. At 9 weeks old, all rats underwent implant surgery on their femurs under general anesthesia. The implant was inserted into the insertion socket prepared at rats’ femur to a depth of 2.5 mm by using a drill at 500 rpm. Nine rats in each group were randomly selected and euthanized at 2 weeks after implantation. The remaining nine rats in each group continued their diets, and were euthanized in the same manner at 4 weeks after implantation. The femur, including the implant, was removed from the body and implant was pulled out by an Instron universal testing machine. After the implant removal, BMA was evaluated by bone surface ratio (BS/BV), bone volume fraction (BV/TV), trabecular thickness (TbTh), trabecular number (TbN), trabecular star volume (Vtr), and micro-CT images. BS/BV, BV/TV, TbTh and Vtr were significantly greater in the rats were fed with SBM than those were fed without SBM at 2 and 4 weeks after implantation (P < 0.05). The present results revealed that SBM improves the peri-implant formation and BMA, prominent with trabecular bone structure. The effect of SBM to improve secondary stability of the implant, and shortening the treatment period should be investigated in the future study.</p></div></front></TEI><affiliations><list><country><li>Japon</li><li>États-Unis</li></country><region><li>État de New York</li></region></list><tree><country name="Japon"><noRegion><name sortKey="Takahashi, Takahiro" sort="Takahashi, Takahiro" uniqKey="Takahashi T" first="Takahiro" last="Takahashi">Takahiro Takahashi</name></noRegion><name sortKey="Kawai, Yasuhiko" sort="Kawai, Yasuhiko" uniqKey="Kawai Y" first="Yasuhiko" last="Kawai">Yasuhiko Kawai</name><name sortKey="Kimoto, Suguru" sort="Kimoto, Suguru" uniqKey="Kimoto S" first="Suguru" last="Kimoto">Suguru Kimoto</name><name sortKey="Nakada, Hiroshi" sort="Nakada, Hiroshi" uniqKey="Nakada H" first="Hiroshi" last="Nakada">Hiroshi Nakada</name><name sortKey="Sakae, Toshiro" sort="Sakae, Toshiro" uniqKey="Sakae T" first="Toshiro" last="Sakae">Toshiro Sakae</name><name sortKey="Sato, Hiroki" sort="Sato, Hiroki" uniqKey="Sato H" first="Hiroki" last="Sato">Hiroki Sato</name><name sortKey="Tanimoto, Yasuhiro" sort="Tanimoto, Yasuhiro" uniqKey="Tanimoto Y" first="Yasuhiro" last="Tanimoto">Yasuhiro Tanimoto</name><name sortKey="Watanabe, Takehiro" sort="Watanabe, Takehiro" uniqKey="Watanabe T" first="Takehiro" last="Watanabe">Takehiro Watanabe</name></country><country name="États-Unis"><region name="État de New York"><name sortKey="Mijares, Dindo" sort="Mijares, Dindo" uniqKey="Mijares D" first="Dindo" last="Mijares">Dindo Mijares</name></region><name sortKey="Zhang, Yu" sort="Zhang, Yu" uniqKey="Zhang Y" first="Yu" last="Zhang">Yu Zhang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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